It is important to make sure that ketamine is used appropriately, and this requires an assessment by a psychiatrist.
Some patients who seek ketamine treatment ultimately decide to try other methods such as combinations of medications or engagement in psychotherapy. Some patients who try ketamine do not wish to continue due to side effects, such as dissociation or nausea.
Ketamine therapy can be used by experienced practitioners to help treat substance addiction, however active substance use is viewed as a contraindication to the use of ketamine for treatment resistant depression, mainly due to the fact that ketamine may interact with alcohol or illicit drugs. Furthermore, the use of substances, particularly alcohol, may cause mood problems, or reduce the effectiveness of treatments for depression or anxiety.